Take part in a clinical trial to help find a new treatment for OCD


**Please note, as of May-2020, recruitment for this trial has now closed.

The researchers will commence data analysis shortly**

The University of Melbourne in conjunction with the University of Queensland & Western Sydney University is currently conducting a clinical trial for individuals with Obsessive-Compulsive Disorder (OCD).

We received funding from the National Health & Medical Research Council (NHMRC; application number 1104460) in 2015 to conduct a multi-centre clinical trial assessing the effects of an amino acid supplement called N-acetylcysteine (NAC). Previous studies have shown that NAC may be beneficial for improving symptoms in some people with OCD, however, questions remain regarding who responds to this treatment, and at what dose.

The study has been approved by The Melbourne Clinic Research Ethics Committee, Western Sydney HREC and UQ HREC. We started recruiting for this trial in 2016 and will continue to enroll participants until June-2020.



  • Taking NAC or placebo capsules twice per day alongside your current treatment for 24 weeks (6 months)

    • The study capsules will be used alongside your current treatment, for example, alongside antidepressant medication which is commonly prescribed for OCD. We are assessing if NAC can provide an additional improvement in symptoms.

  • Attending an appointment each month at one of the following recruitment sites:

    • Melbourne (@ The Melbourne Clinic Professorial Unit in Richmond)

    • Sydney (@ NICM Health Research Institute in Westmead) or

    • Brisbane (@ The Royal Brisbane & Womens Hospital in Herston) **please note, as of Jan-2020 Brisbane have ceased recruitment. Melbourne & Sydney are still accepting new participants**

  • At each appointment, you will meet with a research assistant who will ask you questions about your OCD symptoms, mood and general health. There will also be some questionnaires for you to complete. The first appointment involved in the study can take between 2-3 hours, however, the follow-up appointments will take 60-90 minutes

  • You will be reimbursed $20 (in the form of a Coles Myer giftcard) for each appointment visit you attend

  • There is an optional component in the study which involves having a blood test. We would analyse this sample for specific genes involved in how NAC is metabolised by the body. This may provide insight into why some people respond better to NAC others.



We are still looking for people to take part in this trial at our Melbourne & Western Sydney recruitment sites. If you would like to assess if you are eligible to participate, you can complete the following questionnaire here. Alternatively, submit your contact details using the form below and one of our staff members will be in touch to discuss the study with you. 



Enter your contact details below and one of our staff members will be in touch to discuss the trial with you. However, please note, recruitment for this trial has now closed. 

By providing your contact details, you consent to the storage of this information on our secure research database. This information will be destroyed at the completion of the trial. 

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TMCREC project #279; UQ MREC project #2016001720; WSU HREC project #H12181